In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 6 ·1986-06-00 ·Pages 1092-4

Elwell LP, Wilson HR, Knick VB, Keith BR

Abstract

The in vitro susceptibilities of 16 independent, geographically distinct clinical isolates of methicillin-resistant Staphylococcus aureus to trimethoprim (TMP) in combination with sulfamethoxazole (SMX) were evaluated. Although methicillin-resistant S. aureus strains appear to be universally resistant to SMX, the combination TMP-SMX was found to be synergistic in vitro (in combination, the MICs of both drugs decreased 6- to 25-fold) as well as in vivo (5- to 6-fold reduction in TMP at 50% effective doses).

MeSH Terms

Animals Anti-Bacterial Agents/pharmacology Drug Combinations/pharmacology Drug Synergism Methicillin/pharmacology Mice Penicillin Resistance Staphylococcal Infections/drug therapy Staphylococcus aureus/drug effects Sulfamethoxazole/pharmacology Trimethoprim/pharmacology Trimethoprim, Sulfamethoxazole Drug Combination Vancomycin/pharmacology

Chemicals

Anti-Bacterial Agents Drug Combinations Vancomycin Trimethoprim, Sulfamethoxazole Drug Combination Trimethoprim Sulfamethoxazole Methicillin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Elwell L P

Wilson H R

Knick V B

Keith B R

References (10)

10 references, click to expand

Trimethoprim-sulphamethoxazole treatment in staphylococcal endocarditis and gram-negative septicemia.
Scand J Infect Dis. 1974;6(2):177-82 PMID: 4605402
Treatment of meningitis and septicemia in infancy with a sulphamethoxazole/trimethorpim combination.
Acta Paediatr Scand. 1975 Jan;64(1):25-32 PMID: 1090107
Letter: Trimethoprim-sulfamethoxazole and bacterial meningitis.
Ann Intern Med. 1976 Jan;84(1):50-1 PMID: 1244793
Failure of vancomycin treatment in Staphylococcus aureus endocarditis. In vivo and in vitro observations.
JAMA. 1976 Oct 4;236(14):1604-6 PMID: 989135
Oral rifampin and trimethoprim/sulfamethoxazole therapy in asymptomatic carriers of methicillin-resistant Staphylococcus aureus infections.
West J Med. 1984 May;140(5):735-40 PMID: 6610253
Emergence of gentamicin- and methicillin-resistant Staphylococcus aureus strains in New York City hospitals.
J Clin Microbiol. 1981 Apr;13(4):754-9 PMID: 6908898
Trimethoprim-sulfamethoxazole treatment of multiantibiotic-resistant staphylococcal endocarditis and meningitis.
Clin Pediatr (Phila). 1982 Feb;21(2):125-6 PMID: 7056008
The emergence of methicillin-resistant Staphylococcus aureus.
Ann Intern Med. 1982 Sep;97(3):440-2 PMID: 7114639
In-vitro effects of vancomycin, rifampicin, and fusidic acid, alone and in combination, against methicillin-resistant Staphylococcus aureus.
J Antimicrob Chemother. 1983 Jan;11(1):21-6 PMID: 6826485
Antimicrobial synergism--an elusive concept.
J Infect Dis. 1979 Oct;140(4):639-41 PMID: 390068

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.29.6.1092

Published

1986-06-00

Pages

1092-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC180506

Subset

External Links

PubMed source DOI: 10.1128/AAC.29.6.1092 PMC Full Text View journal details

Analysis Services

In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus.

Contact

WeChat Official Account