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PMID: 3488549 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 15 ·1986-08-00 ·Pages 5531-3

Ristow HJ

Abstract

Growth inhibitor/type beta transforming growth factor purified from BSC-1 cells and human platelets is shown to strongly inhibit the proliferation of Con A-stimulated mouse thymocytes. The inhibition can be achieved with growth inhibitor/type beta transforming growth factor concentrations approximately equal to 1/10th those necessary to inhibit keratinocyte cultures. The inhibitory effect in thymocyte cultures can be reversed by the addition of interleukin 2. These findings suggest that growth inhibitor/type beta transforming growth factor is a naturally occurring immunoregulator.

MeSH Terms

Animals Cell Line Chlorocebus aethiops Growth Inhibitors/pharmacology Interleukin-2/pharmacology Lymphocyte Activation/drug effects Lymphocytes/cytology,drug effects Mice Peptides/pharmacology Skin/cytology Transforming Growth Factors

Chemicals

Growth Inhibitors Interleukin-2 Peptides Transforming Growth Factors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ristow H J

References (13)

13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.83.15.5531

Published

1986-08-00

Pages

5531-3

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC386321

Subset

External Links

PubMed source DOI: 10.1073/pnas.83.15.5531 PMC Full Text View journal details

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