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PMID: 3490583 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity.

Journal of virology ·Vol. 60 ·No. 2 ·1986-11-00 ·Pages 754-60

Terwilliger E, Sodroski JG, Rosen CA, Haseltine WA

Abstract

Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.

MeSH Terms
Cell Line Cell Survival Cytopathogenic Effect, Viral Genes, Viral HIV/genetics,physiology Mutation Retroviridae Proteins/genetics,physiology T-Lymphocytes/microbiology Virus Replication
Chemicals
Retroviridae Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Terwilliger E
Sodroski J G
Rosen C A
Haseltine W A
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30 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.60.2.754-760.1986
Published
1986-11-00
Pages
754-60
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC288951
Subset
IM
Grants
NCI NIH HHS · CA-07580 · United States
NCI NIH HHS · CA-40658 · United States
NCI NIH HHS · CA-42597 · United States
Databases
GENBANK
K03455
External Links
PubMed source DOI: 10.1128/JVI.60.2.754-760.1986 PMC Full Text View journal details
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