A mutation affecting the sigma subunit of RNA polymerase changes transcriptional specificity.

Nature ·Vol. 273 ·No. 5661 ·1978-06-01 ·Pages 354-8

Travers AA, Buckland R, Goman M, Le Grice SS, Scaife JG

Abstract

The RNA polymerase mutation, alt-1, affects the sigma subunit and alters the in vitro selectivity of RNA polymerase to parallel the in vivo phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase isomers.

MeSH Terms

Chromosome Mapping DNA-Directed RNA Polymerases/genetics,metabolism Escherichia coli/enzymology,genetics Genes, Regulator Genetic Linkage Mutation Operon Sigma Factor/genetics Substrate Specificity Transcription Factors/genetics Transcription, Genetic

Chemicals

Sigma Factor Transcription Factors DNA-Directed RNA Polymerases

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Travers A A

Buckland R

Goman M

Le Grice S S

Scaife J G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/273354a0

Published

1978-06-01

Pages

354-8

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/273354a0 View journal details

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A mutation affecting the sigma subunit of RNA polymerase changes transcriptional specificity.

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