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PMID: 3516077 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Early administration of indomethacin to preterm infants.

Archives of disease in childhood ·Vol. 61 ·No. 3 ·1986-03-00 ·Pages 233-8

Rennie JM, Doyle J, Cooke RW

Abstract

Indomethacin (0.2 mg/kg) or saline was given intravenously during the first 24 hours to 50 preterm infants in a double blind controlled trial. Eight of the control group later required treatment with indomethacin for clinical signs of left to right shunt, but only one in the treatment group (p = 0.03). Treatment with indomethacin prolonged bleeding time, raised serum creatinine concentrations, and was associated with gastrointestinal haemorrhage in seven infants. Five of these had a serum indomethacin concentration greater than 1.0 microgram/ml. There was a significant reduction of the stable metabolite of prostacyclin, 6-ketoprostaglandin F1 alpha, commencing six hours after treatment and lasting for four days. There was no significant difference in the incidence of intraventricular haemorrhage, days of treatment with oxygen or ventilation, or mortality between the two groups.

MeSH Terms
6-Ketoprostaglandin F1 alpha/blood Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Ductus Arteriosus, Patent/blood,drug therapy Female Humans Indomethacin/administration & dosage,adverse effects,therapeutic use Infant, Newborn Infant, Premature, Diseases/blood,drug therapy Male
Chemicals
6-Ketoprostaglandin F1 alpha Indomethacin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rennie J M
Doyle J
Cooke R W
References (27)
27 references, click to expand
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Article Info
Journal
Archives of disease in childhood
Abbr.
Arch Dis Child
ISSN
1468-2044
DOI
10.1136/adc.61.3.233
Published
1986-03-00
Pages
233-8
Language
English
Region
England
NLM ID
0372434
PMCID
PMC1777724
Subset
IM
External Links
PubMed source DOI: 10.1136/adc.61.3.233 PMC Full Text View journal details
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