Home LiteratureArticle Details

PMID: 3518775 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children.

British journal of clinical pharmacology ·Vol. 21 ·No. 4 ·1986-04-00 ·Pages 445-9

Levene S, McKenzie SA

Abstract

The bronchial responsiveness of a group of asthmatic children was studied using histamine stimulation after a single dose of theophylline and after placebo. Theophylline, when levels were greater than 10 micrograms ml-1 significantly reduced responsiveness but only by just over one doubling concentration of histamine (P less than 0.001).

MeSH Terms

Adolescent Asthma/drug therapy,physiopathology Bronchi/drug effects Child Child, Preschool Clinical Trials as Topic Histamine/pharmacology Humans Peak Expiratory Flow Rate Theophylline/blood,pharmacology

Chemicals

Histamine Theophylline

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Levene S

McKenzie S A

References (16)

16 references, click to expand

A sustained release theophylline preparation: efficacy in childhood asthma with low serum theophylline levels.
Ann Allergy. 1978 Apr;40(4):252-7 PMID: 345889
Acute and chronic theophylline therapy in exercise-induced bronchospasm.
Pediatrics. 1977 Dec;60(6):845-9 PMID: 600596
Assessment of oral antiasthmatic drugs by inhalation challenges.
J Allergy Clin Immunol. 1979 Dec;64(6 pt 2):685-8 PMID: 389992
Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels.
Thorax. 1980 Jul;35(7):526-30 PMID: 7001670
Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation.
J Allergy Clin Immunol. 1981 Feb;67(2):156-61 PMID: 7451782
Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance.
J Allergy Clin Immunol. 1981 Nov;68(5):347-55 PMID: 7028842
Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.
Thorax. 1981 Aug;36(8):575-9 PMID: 7031972
Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid?
Br Med J (Clin Res Ed). 1982 Mar 20;284(6319):863-6 PMID: 6802327
Comparison of peak expiratory flow rate and forced expiratory volume in one second in histamine challenge studies in children.
Br J Dis Chest. 1982 Apr;76(2):167-70 PMID: 7093136
Reproducibility of histamine challenge tests in asthmatic children.
Thorax. 1983 Apr;38(4):258-60 PMID: 6867976
Nocturnal asthma: mechanisms and treatment.
Br Med J (Clin Res Ed). 1984 May 12;288(6428):1397-8 PMID: 6426574
Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children.
J Pediatr. 1974 Mar;84(3):421-7 PMID: 4590718
Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study.
Lancet. 1977 Feb 19;1(8008):381-5 PMID: 65508
Bronchial reactivity to inhaled histamine: a method and clinical survey.
Clin Allergy. 1977 May;7(3):235-43 PMID: 908121
Protective effect of drugs on histamine-induced asthma.
Thorax. 1977 Aug;32(4):429-37 PMID: 145036
Bronchial provocation tests.
Br J Clin Pharmacol. 1979 Nov;8(5):417-24 PMID: 41562

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1986.tb05220.x

Published

1986-04-00

Pages

445-9

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1400938

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1986.tb05220.x PMC Full Text View journal details

Analysis Services

Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children.

Contact

WeChat Official Account