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PMID: 3519253 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Modulators of the eukaryotic heat shock response.

Experimental cell research ·Vol. 165 ·No. 1 ·1986-07-00 ·Pages 1-10

Lanks KW

Abstract

A wide variety of agents other than heat have been reported to induce or suppress heat shock protein (hsp) synthesis in eukaryotic cells. Such agents, termed 'modulators', include inhibitors of respiration, low molecular weight nutrients, oxygen, hormones, sulfhydryl reagents, ionophores and amino acid analogues. The evidence for modulation is critically reviewed and common mechanisms of action that may relate modulation to induction by heat are discussed.

MeSH Terms

Adenosine Triphosphate/physiology Animals Cell Differentiation Drosophila Energy Metabolism Glucocorticoids/physiology Glucose/metabolism Heat-Shock Proteins/physiology Insulin/physiology Ionophores/pharmacology Leishmania Mitochondria/metabolism NAD/metabolism NADP/metabolism Oxidation-Reduction/drug effects Protein Biosynthesis Sulfhydryl Reagents/pharmacology Xenopus

Chemicals

Glucocorticoids Heat-Shock Proteins Insulin Ionophores Sulfhydryl Reagents NAD NADP Adenosine Triphosphate Glucose

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lanks K W

Article Info

Journal

Experimental cell research

Abbr.

Exp Cell Res

ISSN

0014-4827

DOI

10.1016/0014-4827(86)90528-8

Published

1986-07-00

Pages

1-10

Language

English

Region

United States

NLM ID

0373226

Subset

Grants

NIGMS NIH HHS · GM32725 · United States

External Links

PubMed source DOI: 10.1016/0014-4827(86)90528-8 View journal details

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Modulators of the eukaryotic heat shock response.

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