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PMID: 3519621 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Brain spectrin(240/235) and brain spectrin(240/235E): two distinct spectrin subtypes with different locations within mammalian neural cells.

The Journal of cell biology ·Vol. 102 ·No. 6 ·1986-06-00 ·Pages 2088-97

Riederer BM, Zagon IS, Goodman SR

Abstract

Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.

MeSH Terms
Animals Axons/analysis Brain Chemistry Dendrites/analysis Immune Sera/analysis Immunoenzyme Techniques Mice Neurons/analysis Organ Specificity Spectrin/immunology,isolation & purification Synaptic Membranes/analysis
Chemicals
Immune Sera Spectrin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Riederer B M
Zagon I S
Goodman S R
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40 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.102.6.2088
Published
1986-06-00
Pages
2088-97
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2114251
Subset
IM
Grants
NHLBI NIH HHS · HL-26059 · United States
NINDS NIH HHS · NS-19357 · United States
NINDS NIH HHS · NS-21246 · United States
External Links
PubMed source DOI: 10.1083/jcb.102.6.2088 PMC Full Text View journal details
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