Psychomotor changes during initial day of benzodiazepine medication.
1 The detracting psychomotor effects of diazepam (5 mg three times daily) and clobazam (an investigational 1,5-benzodiazepine) were compared with placebo effects over the course of the initial day of medication. Tests were administered at hourly intervals and the data were analyzed from the standpoint of contrasts at each session and from the standpoint of trends that accrued during the course of the day. 2 It is concluded that among normal volunteers diazepam 5 mg three times daily may be near the threshold for detracting psychomotor consequences during the initial day and that clobazam seems to be without detracting consequences and may have some enhancing effects.
10 references, click to expand
-
The effect of diazepam and fentanyl on mental, psychomotor and electroencephalographic functions and their rate of recovery.Psychopharmacologia. 1975 Oct 14;44(1):61-6 PMID: 1105627
-
Immediate effects on human performance of a 1,5-genzodiazepine (clobazam) compared with the 1,4-benzodiazepines, chlordiazepoxide hydrochloride and diazepam.Br J Clin Pharmacol. 1975 Jun;2(3):215-21 PMID: 1234503
-
Judgment of time as a function of serial position and stress.J Exp Psychol. 1954 Apr;47(4):279-82 PMID: 13152309
-
COMPARATIVE EFFECT IN HUMAN SUBJECTS OF CHLORDIAZEPOXIDE, DIAZEPAM, AND PLACEBO ON MENTAL AND PHYSICAL PERFORMANCE.Clin Pharmacol Ther. 1965 Mar-Apr;6:139-45 PMID: 14288182
-
Covert effects of chlordiazepoxide therapy.J Neuropsychiatr. 1962 Jan-Feb;3:168-70 PMID: 14477480
-
Influence of personality type on drug response.Am J Psychiatry. 1966 Apr;122(10):1153-8 PMID: 4379563
-
Delayed recovery from a sedative: correlation of the plasma levels of diazepam with clinical effects after oral and intravenous administration.Br J Anaesth. 1972 Aug;44(8):803-8 PMID: 5083012
-
The effects of diazepam or diphenhydramine on healthy human subjects.Psychopharmacologia. 1971;21(3):202-11 PMID: 5095411
-
Stimulus variation and sequential judgements of duration.Q J Exp Psychol. 1966 Nov;18(4):354-7 PMID: 5956078
-
A comparison of the effect of imipramine, nomifensine, and placebo on the psychomotor performance of normal males.Psychopharmacology (Berl). 1976 Dec 21;51(1):85-90 PMID: 827779
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
