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PMID: 3521490 Published · ppublish English Journal Article

Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 3 ·1986-03-00 ·Pages 535-8

Hirai K, Aoyama H, Irikura T, Iyobe S, Mitsuhashi S

Abstract

The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quinolones such as nalidixic acid but not for hydrophilic quinolones such as norfloxacin and ciprofloxacin. The results also showed that quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a high relative hydrophobicity appeared to permeate through both OmpF porin and phospholipid bilayers.

MeSH Terms
Cell Membrane/metabolism Drug Resistance, Microbial Escherichia coli/drug effects,genetics,metabolism Mutation Quinolines/metabolism,pharmacology Salmonella typhimurium/drug effects,genetics,metabolism
Chemicals
Quinolines
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hirai K
Aoyama H
Irikura T
Iyobe S
Mitsuhashi S
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23 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.29.3.535
Published
1986-03-00
Pages
535-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180431
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/AAC.29.3.535 PMC Full Text View journal details
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