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PMID: 3521546 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Effect of carboxylic ionophores on measles virus hemagglutinin protein.

Archives of virology ·Vol. 89 ·No. 1-4 ·1986-00-00 ·Pages 213-23

Kohama T, Fukuda A, Sugiura A

Abstract

We have studied the effect of two carboxylic ionophores, monensin and laidlomycin, on the replication of measles virus in KB cells. The yield of infectious virus was markedly depressed at the concentrations of the ionophores which had no effect on overall viral protein synthesis. The ionophores selectively blocked the migration of hemagglutinin (H) glycoprotein from Golgi apparatus to the cell surface. As a result, H glycoprotein is prevented from being converted from incompletely glycosylated form to the mature form. The inhibitory effect on the transport and glycosylation of H was reversed, although gradually, upon the removal of the ionophores.

MeSH Terms
Anti-Bacterial Agents/pharmacology Cell Transformation, Viral DNA Replication/drug effects Fluorescent Antibody Technique Furans/pharmacology Hemagglutinins, Viral/genetics Humans KB Cells/metabolism Kinetics Measles virus/drug effects,genetics,immunology Monensin/analogs & derivatives,pharmacology Virus Replication/drug effects
Chemicals
Anti-Bacterial Agents Furans Hemagglutinins, Viral Monensin laidlomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kohama T
Fukuda A
Sugiura A
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26 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01309890
Published
1986-00-00
Pages
213-23
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01309890 View journal details
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