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PMID: 352259 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S.

Human leukocyte interferon in the treatment of varicella in children with cancer: a preliminary controlled trial.

Antimicrobial agents and chemotherapy ·Vol. 13 ·No. 4 ·1978-04-00 ·Pages 605-7

Arvin AM, Feldman S, Merigan TC

Abstract

Eighteen patients who developed varicella while being treated for malignancy received human leukocyte interferon in a randomized double-blind placebo-controlled trial. Complications of varicella occurred in six of nine placebo recipients, but in only two of nine interferon recipients. Interferon was tolerated without significant side effects.

MeSH Terms
Blood Cell Count Chickenpox/complications,drug therapy,microbiology Child Clinical Trials as Topic Humans Interferons/adverse effects,therapeutic use Leukocytes/physiology Neoplasms/complications Placebos
Chemicals
Placebos Interferons
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Arvin A M
Feldman S
Merigan T C
References (5)
5 references, click to expand
  1. A COMPLEMENT-FIXING ANTIGEN FOR VARICELLA-ZOSTER DERIVED FROM INFECTED CULTURES OF HUMAN FETAL DIPLOID CELLS.
    Proc Soc Exp Biol Med. 1964 May;116:144-9 PMID: 14200088
  2. Varicella in children with cancer: Seventy-seven cases.
    Pediatrics. 1975 Sep;56(3):388-97 PMID: 1088828
  3. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis.
    N Engl J Med. 1976 Sep 2;295(10):517-22 PMID: 950957
  4. Adenine arabinoside therapy of herpes zoster in the immunosuppressed. NIAID collaborative antiviral study.
    N Engl J Med. 1976 May 27;294(22):1193-9 PMID: 177866
  5. Zoster immune globulin. A further assessment.
    N Engl J Med. 1974 Jan 31;290(5):243-5 PMID: 4358055
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.13.4.605
Published
1978-04-00
Pages
605-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC352295
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.13.4.605 PMC Full Text View journal details
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