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PMID: 3524434 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparison of norfloxacin and nalidixic acid for treatment of dysentery caused by Shigella dysenteriae type 1 in adults.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 5 ·1986-05-00 ·Pages 883-6

Rogerie F, Ott D, Vandepitte J, Verbist L, Lemmens P, Habiyaremye I

Abstract

A severe epidemic of dysentery began late in 1979 in northeast Zaire and spread to Rwanda, Burundi, and Tanzania. The epidemic strain is a multiply resistant Shigella dysenteriae type 1, which acquired resistance against trimethoprim and more recently against nalidixic acid in the course of the epidemic. A comparative open trial in Rwandan adults with Shiga dysentery involved 18 patients treated with norfloxacin at 400 mg twice daily and 12 patients treated with nalidixic acid at 1 g three times daily for 5 days. All isolates showed in vitro susceptibility to both drugs. Though norfloxacin eliminated Shigella organisms from stools more rapidly than nalidixic acid, its clinical superiority did not reach the level of significance. Norfloxacin is a promising drug and is more effective than nalidixic acid in the treatment of multiresistant shigellosis.

MeSH Terms
Adolescent Adult Dysentery, Bacillary/drug therapy,microbiology Female Humans Male Middle Aged Nalidixic Acid/therapeutic use Norfloxacin/therapeutic use Rwanda Shigella dysenteriae
Chemicals
Nalidixic Acid Norfloxacin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rogerie F
Ott D
Vandepitte J
Verbist L
Lemmens P
Habiyaremye I
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24 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.29.5.883
Published
1986-05-00
Pages
883-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284172
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.29.5.883 PMC Full Text View journal details
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