-
Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.
J Lab Clin Med. 1969 Jun;73(6):934-9
PMID: 4182334
-
Human alpha 1-antitrypsin expression in Xenopus oocytes. Secretion of the normal (PiM) and abnormal (PiZ) forms.
Eur J Biochem. 1985 Dec 2;153(2):361-5
PMID: 3878282
-
Liver in alpha1-antitrypsin deficiency: morphologic observations and in vitro synthesis of alpha1-antitrypsin.
Pediatr Res. 1976 Jan;10(1):35-40
PMID: 1082120
-
Liver disease in alpha1-antitrypsin deficiency detected by screening of 200,000 infants.
N Engl J Med. 1976 Jun 10;294(24):1316-21
PMID: 1083485
-
Elastase, collagenase, emphysema, and alpha1-antitrypsin deficiency.
Chest. 1976 Jul;70(1):62-7
PMID: 179761
-
Demonstration of granulocytic proteases in plasma of patients with acute leukemia and septicemia with coagulation defects.
Blood. 1977 Feb;49(2):219-31
PMID: 299817
-
Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.
J Biol Chem. 1978 Oct 25;253(20):7142-4
PMID: 701239
-
Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.
Am Rev Respir Dis. 1978 Sep;118(3):617-21
PMID: 101105
-
Natural history and life expectancy in severe alpha1-antitrypsin deficiency, Pi Z.
Acta Med Scand. 1978;204(5):345-51
PMID: 309708
-
The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center.
J Biol Chem. 1979 May 25;254(10):4022-6
PMID: 312289
-
In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.
J Clin Invest. 1979 Apr;63(4):793-7
PMID: 220283
-
Characterization of the inactive fragment resulting from limited proteolysis of human alpha1-proteinase inhibitor by Crotalus adamanteus proteinase II.
J Biol Chem. 1979 Jun 25;254(12):5317-20
PMID: 447652
-
A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor.
Biochem Biophys Res Commun. 1980 Jul 31;95(2):864-71
PMID: 6968211
-
Heterozygous MZ alpha 1-antitrypsin deficiency in adults with chronic active hepatitis and cryptogenic cirrhosis.
N Engl J Med. 1981 Mar 5;304(10):557-60
PMID: 6969850
-
Effect of human granulocytic elastase on isolated human antithrombin III.
Hoppe Seylers Z Physiol Chem. 1981 Feb;362(2):103-12
PMID: 6783500
-
Four-year-old children with alpha 1-antitrypsin deficiency. Clinical follow-up and parental attitudes towards neonatal screening.
Acta Paediatr Scand. 1981 Mar;70(2):171-7
PMID: 6972148
-
Transport of proteases across neonatal intestine and development of liver disease in infants with alpha-1 antitrypsin deficiency.
Lancet. 1982 Jun 26;1(8287):1441-3
PMID: 6123724
-
Structure and variation of human alpha 1-antitrypsin.
Nature. 1982 Jul 22;298(5872):329-34
PMID: 7045697
-
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.
J Biol Chem. 1982 Aug 25;257(16):9849-54
PMID: 6980881
-
Liver disease and alpha 1-antitrypsin deficiency.
Lancet. 1982 Oct 30;2(8305):983-4
PMID: 6127479
-
In vitro synthesis of M and Z forms of human alpha 1-antitrypsin.
FEBS Lett. 1982 Nov 1;148(1):83-6
PMID: 6983458
-
Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.
J Clin Invest. 1983 Mar;71(3):754-61
PMID: 6600748
-
Complement and the damaging effects of cardiopulmonary bypass.
Thorax. 1983 May;38(5):321-5
PMID: 6603674
-
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder.
N Engl J Med. 1983 Sep 22;309(12):694-8
PMID: 6604220
-
Human plasma proteinase inhibitors.
Annu Rev Biochem. 1983;52:655-709
PMID: 6193754
-
Translation and processing of normal (PiMM) and abnormal (PiZZ) human alpha 1-antitrypsin.
FEBS Lett. 1983 Mar 21;153(2):270-4
PMID: 6604664
-
Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.
J Clin Invest. 1984 May;73(5):1297-303
PMID: 6325501
-
Is alpha 1-protease inhibitor inactivated by smoking?
Science. 1984 May 18;224(4650):755-6
PMID: 6609431
-
Purification of human plasma alpha 1-proteinase inhibitor and its inactivation by Pseudomonas aeruginosa elastase.
J Biochem. 1984 Mar;95(3):795-804
PMID: 6427201
-
Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function.
J Mol Biol. 1984 Aug 15;177(3):531-57
PMID: 6332197
-
Ultrastructural liver pathology in patients with minimal liver disease and alpha 1-antitrypsin deficiency: a comparison between heterozygous and homozygous patients.
Hepatology. 1984 Sep-Oct;4(5):937-45
PMID: 6332768
-
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.
Nature. 1984 Nov 1-7;312(5989):77-80
PMID: 6387509
-
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liver.
FEBS Lett. 1984 Nov 19;177(2):179-83
PMID: 6333994
-
A genetically engineered mutant of alpha 1-antitrypsin protects connective tissue from neutrophil damage and may be useful in lung disease.
Lancet. 1984 Dec 22;2(8417-8418):1426-8
PMID: 6151045
-
Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis.
Nature. 1985 Jan 10-18;313(5998):149-51
PMID: 3880873
-
Smoking, lung function, and alpha 1-antitrypsin deficiency.
Lancet. 1985 Jan 19;1(8421):152-4
PMID: 2857224
-
Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages.
Proc Natl Acad Sci U S A. 1985 Feb;82(3):795-9
PMID: 3871944
-
Human Z alpha 1-antitrypsin accumulates intracellularly and stimulates lysosomal activity when synthesised in the Xenopus oocyte.
FEBS Lett. 1985 Apr 22;183(2):304-8
PMID: 3872810
-
Further evidence for a cell surface proteinase essential to the growth of cultured fibroblasts.
Exp Cell Res. 1985 May;158(1):41-52
PMID: 3888646
-
Regulation of alpha 1 proteinase inhibitor function by rabbit alveolar macrophages. Evidence for proteolytic rather than oxidative inactivation.
J Clin Invest. 1985 Jun;75(6):1758-62
PMID: 2989330
-
DNA restriction fragments associated with alpha 1-antitrypsin indicate a single origin for deficiency allele PI Z.
Nature. 1985 Jul 4-10;316(6023):79-81
PMID: 2989709
-
Eglin c, a pharmacologically active elastase inhibitor.
Eur J Respir Dis Suppl. 1985;139:66-70
PMID: 3862612
-
Alpha 1-antitrypsin and serum albumin mRNA accumulation in normal, acute phase and ZZ human liver.
FEBS Lett. 1985 Sep 23;189(2):361-6
PMID: 3876243
-
What turns on heat shock genes?
Nature. 1985 Oct 10-16;317(6037):477-8
PMID: 2995833
-
The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA.
Proc Natl Acad Sci U S A. 1985 Oct;82(20):6918-21
PMID: 3876562
-
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis.
Nature. 1985 Oct 24-30;317(6039):730-2
PMID: 3877243
-
Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemia after abdominal surgery.
Surgery. 1985 Nov;98(5):892-9
PMID: 2414855
-
Cirrhosis and malignant hepatoma in alpha 1-antitrypsin deficiency.
Acta Med Scand. 1974 Jun;195(6):451-8
PMID: 4365922