Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type.
Using a costimulant assay, in vitro Con A responses of patients across the leprosy spectrum were found to be markedly suppressed by phenolic glycolipid-I (PGL-I), a unique antigen of M. leprae. The degree of inducible suppression as well as the number of leprosy patients showing suppression of mitogenic responses was higher with PGL-I as compared with integral M. leprae (p less than 0.05 to less than 0.01). Both untreated lepromatous (60%) as well as tuberculoid leprosy (67%) patients showed significant suppression ranging from 13 to 64% and 12 to 79%, respectively. Thus, PGL-I appears to have a universal suppressive effect on Con A responses and is unlikely to play a central role in determining the leprosy spectrum.
15 references, click to expand
-
Antigen-specific suppressor cells in subclinical leprosy infection.Lancet. 1981 Dec 19-26;2(8260-61):1372-7 PMID: 6171698
-
Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.Clin Exp Immunol. 1980 Nov;42(2):203-10 PMID: 6451335
-
Studies on the defect in cell-mediated immunity in lepromatous leprosy using HLA-D-identical siblings. Absence of circulating suppressor cells and evidence that the defect is in the T-lymphocyte, rather than the monocyte, population.Scand J Immunol. 1982 Jan;15(1):33-48 PMID: 6176016
-
Aberrant immunoregulatory control of B lymphocyte function in lepromatous leprosy.Clin Exp Immunol. 1982 Jul;49(1):105-14 PMID: 6751630
-
Serological activity of a characteristic phenolic glycolipid from Mycobacterium leprae in sera from patients with leprosy and tuberculosis.Clin Exp Immunol. 1983 May;52(2):271-9 PMID: 6407793
-
Monocyte-derived soluble suppressor factor(s) in patients with lepromatous leprosy.Infect Immun. 1983 Dec;42(3):890-9 PMID: 6605932
-
Generation and characterization of monoclonal antibodies to the phenolic glycolipid of Mycobacterium leprae.Infect Immun. 1984 Jan;43(1):183-8 PMID: 6360894
-
Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid.Nature. 1984 Mar 8-14;308(5955):194-6 PMID: 6366573
-
A logarithmic index of bacilli in biopsies. I. Method.Int J Lepr Other Mycobact Dis. 1967 Apr-Jun;35(2):184-6 PMID: 5338960
-
Classification of leprosy according to immunity. A five-group system.Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255-73 PMID: 5950347
-
Inhibition of interleukin-2 production by adherent cell factors from lepromatous leprosy patients.Clin Exp Immunol. 1984 Dec;58(3):531-8 PMID: 6334579
-
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.Scand J Clin Lab Invest Suppl. 1968;97:77-89 PMID: 4179068
-
Lepromin-induced suppressor cells in patients with leprosy.J Immunol. 1979 Oct;123(4):1813-7 PMID: 158056
-
The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.Clin Exp Immunol. 1980 Sep;41(3):406-14 PMID: 7002396
-
Studies on T cell subsets and functions in leprosy.Clin Exp Immunol. 1981 Jun;44(3):491-500 PMID: 6459897
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
