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PMID: 3542564 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

c-Ha-ras gene products are potent inhibitors of cathepsins B and L.

FEBS letters ·Vol. 211 ·No. 1 ·1987-01-19 ·Pages 23-6

Hiwasa T, Yokoyama S, Ha JM, Noguchi S, Sakiyama S

Abstract

c-Ha-ras proteins produced by Escherichia coli inhibited the activities of cathepsins B and L which had been partially purified from rat kidney. Furthermore, amino acid sequence homology between c-Ha-ras proteins and thiol proteinase inhibitors has been found.

MeSH Terms

Amino Acid Sequence Animals Cathepsin B/antagonists & inhibitors,isolation & purification Cathepsin L Cathepsins/antagonists & inhibitors,isolation & purification Cysteine Endopeptidases Endopeptidases Kidney/enzymology Kinetics Oncogenes Proto-Oncogene Proteins/genetics,pharmacology Proto-Oncogene Proteins p21(ras) Rats Sequence Homology, Nucleic Acid Structure-Activity Relationship

Chemicals

Proto-Oncogene Proteins Cathepsins Endopeptidases Cysteine Endopeptidases Cathepsin B Cathepsin L Ctsl protein, rat Proto-Oncogene Proteins p21(ras)

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hiwasa T

Yokoyama S

Ha J M

Noguchi S

Sakiyama S

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(87)81266-8

Published

1987-01-19

Pages

23-6

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(87)81266-8 View journal details

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c-Ha-ras gene products are potent inhibitors of cathepsins B and L.

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