A comparative study of ciprofloxacin and trimethoprim in the treatment of urinary tract infections in geriatric patients.

A prospective, comparative clinical trial of ciprofloxacin (100 mg bd) versus trimethoprim (200 mg bd), both for five days, was carried out in 40 geriatric patients with urinary tract infection. Thirty-two could be assessed for drug efficacy, and all forty for toxicity studies. Both drugs were equally safe, and ciprofloxacin was at least as effective as trimethoprim as far as clinical response was concerned. Ciprofloxacin appeared more effective in eradication of bacteria. Antibacterial activity was found in urine and faeces up to five days after stopping ciprofloxacin therapy.