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LiteratureArticle Details
PMID: 3543689
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
A cytosolic protein contains a cryptic mitochondrial targeting signal.
Abstract
Cytosolic dihydrofolate reductase from mouse contains a cryptic mitochondrial targeting sequence. If this sequence is attached to the amino terminus of 'passenger' proteins which by themselves cannot enter mitochondria, the resulting fusion proteins are transported into yeast mitochondria.
MeSH Terms
Amino Acid Sequence
Animals
Biological Transport
Chickens/genetics
Cytosol/enzymology
Mice/genetics
Mitochondria/metabolism
Protein Conformation
Recombinant Fusion Proteins/metabolism
Recombinant Proteins/metabolism
Saccharomyces cerevisiae/metabolism
Tetrahydrofolate Dehydrogenase/genetics,metabolism
Chemicals
Recombinant Fusion Proteins
Recombinant Proteins
Tetrahydrofolate Dehydrogenase
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1987-00-00
Pages
499-503
Language
English
Region
England
NLM ID
0410462
Subset
IM
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