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PMID: 35482070 Published · ppublish English Journal Article

Neuronal pentraxin-2 (NPTX2) serum levels during an acute psychotic episode in patients with schizophrenia.

Psychopharmacology ·Vol. 239 ·No. 8 ·2022-08-00 ·Pages 2585-2591

Göverti D, Büyüklüoğlu N, Kaya H, Yüksel RN, Yücel Ç, Göka E

Abstract

Neuronal pentraxin-2 (NPTX2, an immediate-early gene), which regulates synapse activity and neuroplasticity, plays an essential role in the neurodevelopmental process. NPTX2 possibly enhances the accumulation of amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptors (AMPAR) on the postsynaptic membranes and stimulates excitatory synaptogenesis. We aimed to evaluate the plasma concentrations of NPTX2 of patients with schizophrenia in acute psychotic episodes compared with matched community-based controls. Ninety-three (93) patients diagnosed with schizophrenia according to DSM-5 and 83 healthy controls were included. The patients, all of which were in acute psychotic episodes, were recruited from the inpatient clinic. The patients were assessed by the Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression- Severity (CGIS) scale, whereas the healthy subjects were evaluated with Structured Clinical Interview for DSM-5 (SCID-5) to exclude any major psychiatric diagnoses. NPTX2 serum concentrations were significantly higher in the schizophrenia group (p < 0.001). NPTX2 levels negatively correlated with age (p = 0.004) and PANSS-positive symptom scores (p < 0.001). The most determinant factors in predicting the change in NPTX2 levels were PANSS-positive symptom and general psychopathology scores. We conclude that NPTX2 could be involved in schizophrenia pathophysiology and valuable as a synapse-derived and glutamate-related biomarker. Further studies in larger samples assessing NPTX2 levels in remitted schizophrenia patients and combining neuroimaging techniques and cognitive evaluations with blood samples are needed.

Keywords
Excitotoxicity Narp Neuronal pentraxins Neuroplasticity Schizophrenia
MeSH Terms
C-Reactive Protein Humans Nerve Tissue Proteins/genetics Psychotic Disorders/diagnosis Schizophrenia Pentraxins
Chemicals
C-Reactive Protein Nerve Tissue Proteins Pentraxins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Göverti Diğdem
Department of Psychiatry, University of Health Sciences, Erenkoy Mental Health and Neurologic Disorders Training and Research Hospital, Istanbul, Turkey. [email protected].
Büyüklüoğlu Nihan
Department of Psychiatry, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Kaya Hasan
Department of Psychiatry, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Yüksel Rabia Nazik
Department of Psychiatry, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Yücel Çiğdem
Department of Biochemistry, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Göka Erol
Department of Psychiatry, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
1432-2072
DOI
10.1007/s00213-022-06147-z
Email
[email protected]
Published
2022-08-00
Epub
2022-00-28
Pages
2585-2591
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/s00213-022-06147-z View journal details
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