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PMID: 355892 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Correlation of nonsense sites in the lacI gene with specific codons in the nucleotide sequence.

Nature ·Vol. 274 ·No. 5673 ·1978-08-24 ·Pages 770-5

Miller JH, Coulondre C, Farabaugh PJ

Abstract

Nonsense mutations derived from 90 different codons in the lacI gene of Escherichia coli have been correlated with the I gene nucleotide sequence. In over 80 cases the specific codon which generates the nonsense mutation can be identified. The sequence shows that 14-16 sites arise through tandem double base changes.

MeSH Terms
Amino Acid Sequence Amino Acids/genetics Base Sequence Codon Escherichia coli/genetics Genes Genes, Regulator Lactose/genetics Mutation Peptide Chain Termination, Translational RNA, Messenger
Chemicals
Amino Acids Codon RNA, Messenger Lactose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Miller J H
Coulondre C
Farabaugh P J
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/274770a0
Published
1978-08-24
Pages
770-5
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
J01636, J01637, K01483, K01793
External Links
PubMed source DOI: 10.1038/274770a0 View journal details
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