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PMID: 355997 Published · ppublish English Comparative Study Journal Article

The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets.

Pflugers Archiv : European journal of physiology ·Vol. 373 ·No. 3 ·1978-03-20 ·Pages 237-42

Malaisse WJ, Boschero AC, Kawazu S, Hutton JC

Abstract

The effect of glucose upon the handling of K+ by islets of Langerhans removed from normal rats was investigated by measuring both the net uptake of 86Rb+ and its efflux from prelabelled islets. The inflow of K+ into islet cells is mediated, in part at least, by an ouabain-sensitive pump. Glucose fails to affect the inflow rate of K+, but it apparently decreases the permeability of islet cells plasma membrane to effuent K+. The glucose-induced change in permeability is a rapid and rapidly reversible phenomenon. Under steady-state conditions, it leads to an increase in the islet cells K+ pool and a decrease of its fractional turnover rate.

MeSH Terms
Animals Cell Membrane Permeability/drug effects Dose-Response Relationship, Drug Female Glucose/pharmacology In Vitro Techniques Islets of Langerhans/drug effects,metabolism Ouabain/pharmacology Potassium/metabolism Rats Rubidium/pharmacology Time Factors
Chemicals
Ouabain Glucose Rubidium Potassium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Malaisse W J
Boschero A C
Kawazu S
Hutton J C
References (21)
21 references, click to expand
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00580830
Published
1978-03-20
Pages
237-42
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00580830 View journal details
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