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PMID: 356054 Published · ppublish English Journal Article

Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 7 ·1978-07-00 ·Pages 3395-9

Parant M, Parant F, Chedid L

Abstract

N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) and certain derivatives that are structural analogs of part of the bacterial peptidoglycan monomer have been shown to be adjuvant active and to enhance the nonspecific immunity of adult mice infected by Klebsiella pneumoniae. In the present study muramyl dipeptide and two other synthetic analogs were found to be active in newborn mice. This activity could be demonstrated after administration by subcutaneous or even by oral route. In contrast to what was observed after treatment by lipopolysaccharide, 8-day-old mice were definitively protected against bacterial challenge by these glycopeptides. Therefore such molecules could have a great value in view of studying and correcting the neonate's unresponsiveness.

MeSH Terms
Adjuvants, Immunologic/therapeutic use Adrenalectomy Animals Animals, Newborn/immunology Glycopeptides/administration & dosage,immunology Immunity, Innate Klebsiella Infections/immunology,prevention & control Klebsiella pneumoniae/immunology Lipopolysaccharides/immunology Mice Muramic Acids/immunology Phagocytosis
Chemicals
Adjuvants, Immunologic Glycopeptides Lipopolysaccharides Muramic Acids
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Parant M
Parant F
Chedid L
References (34)
34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.7.3395
Published
1978-07-00
Pages
3395-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392783
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.7.3395 PMC Full Text View journal details
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