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PMID: 3566257 Published · ppublish English Journal Article

Concentration of norfloxacin in human gallbladder tissue and bile after single-dose oral administration.

Antimicrobial agents and chemotherapy ·Vol. 31 ·No. 2 ·1987-02-00 ·Pages 352-3

Dan M, Serour F, Gorea A, Levenberg A, Krispin M, Berger SA

Abstract

Concomitant concentrations of norfloxacin in serum and in gallbladder tissue and bile were determined in 10 patients after a single oral dose of 400 mg given before cholecystectomy. Concentrations in gallbladder bile ranged from 0.6 to 15.6 micrograms/ml, with a mean bile/serum ratio of 7.0. The mean concentration in gallbladder tissue was 1.8 +/- 0.8 (standard error) micrograms/g.

MeSH Terms
Adult Aged Bile/metabolism Female Gallbladder/metabolism Humans Male Middle Aged Norfloxacin/metabolism Tissue Distribution
Chemicals
Norfloxacin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Dan M
Serour F
Gorea A
Levenberg A
Krispin M
Berger S A
References (4)
4 references, click to expand
  1. In vitro antibacterial activity of norfloxacin compared with eight other antimicrobial agents.
    Eur J Clin Microbiol. 1983 Jun;2(3):230-4 PMID: 6224678
  2. The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans.
    Antimicrob Agents Chemother. 1985 Nov;28(5):716-21 PMID: 2936302
  3. Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
    Drugs. 1985 Dec;30(6):482-513 PMID: 3908074
  4. The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.
    Antimicrob Agents Chemother. 1985 Oct;28(4):581-6 PMID: 3000292
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.31.2.352
Published
1987-02-00
Pages
352-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC174726
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.31.2.352 PMC Full Text View journal details
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