Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro.

Infection and immunity ·Vol. 22 ·No. 3 ·1978-12-00 ·Pages 631-6

Alexander J, Smith CC

Abstract

Mycobacterium lepraemurium cells were found to multiply in normal mouse peritoneal-derived and bone marrow-derived macrophages in vitro. Whereas activated peritoneal-derived macrophages demonstrated marked bacteriostasis for M. lepraemurium, significant bactericidal activity was exhibited by activated bone marrow-derived macrophages. However, only a small proportion of the bacterial were killed by activated bone marrow-derived macrophages with subsequent and enhanced bacteria growth. It is suggested that a rapid turnover of monocytes in active lesions is required to control mycobacterial infections in vivo. These results would suggest that careful consideration be given to the choice of the host cell in studies involving obligate intracellular parasites.

MeSH Terms

Antigens, Bacterial Ascitic Fluid/cytology Bone Marrow Cells Cells, Cultured Lymphocytes Macrophages/immunology,microbiology Mycobacterium lepraemurium/growth & development,immunology

Chemicals

Antigens, Bacterial

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Alexander J

Smith C C

References (25)

25 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.22.3.631-636.1978

Published

1978-12-00

Pages

631-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422205

Subset

External Links

PubMed source DOI: 10.1128/iai.22.3.631-636.1978 PMC Full Text View journal details

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Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro.

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