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PMID: 365763 Published · ppublish English Comparative Study Journal Article

Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice.

Infection and immunity ·Vol. 22 ·No. 3 ·1978-12-00 ·Pages 657-64

Nakamura RM, Tokunaga T

Abstract

Delayed-type hypersensitivity to BCG was remarkably different in two inbred strains of mice, SWM/Ms and C3H/He, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. High responsiveness in the SWM/Ms strain appeared to be dominant over low responsiveness in the C3H/He strain. Results of the footpad reaction test if F1, F2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by a gene which was transmitted under Mendel's laws and was possibly non-H-2 linked. The spleen cells and their nylon wool nonadherent fraction from BCG-infected C3H/He mice were not reactive to purified protein derivative in vitro, whereas both the spleen cells and the nylon wool nonadherent fraction from BCG-infected SWM/Ms mice reacted well to purified protein derivative. Possible mechanisms of the different responses in the delayed-type hypersensitivity to BCG were discussed.

MeSH Terms
Animals Antigens, Bacterial/immunology BCG Vaccine Genes, Dominant Genetic Linkage Hypersensitivity, Delayed Lymphocyte Activation Mice Mice, Inbred C3H Mice, Inbred Strains Mycobacterium bovis/immunology Species Specificity
Chemicals
Antigens, Bacterial BCG Vaccine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nakamura R M
Tokunaga T
References (19)
19 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.22.3.657-664.1978
Published
1978-12-00
Pages
657-64
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422210
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.22.3.657-664.1978 PMC Full Text View journal details
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