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PMID: 365764 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Nonspecific and specific immunological mitogenicity by group A streptococcal pyrogenic exotoxins.

Infection and immunity ·Vol. 22 ·No. 3 ·1978-12-00 ·Pages 681-8

Barsumian EL, Schlievert PM, Watson DW

Abstract

Group A streptococcal pyrogenic exotoxin (SPE) types A, B, and C induced lymphocyte proliferation both specifically and nonspecifically, and the responses showed characteristics associated with both types of stimulation. Guinea pig lymphocytes from animals presensitized to SPE A displayed immunologically specific proliferation in response to SPE A; control lymphocytes showed little activity in the presence of SPE A. Lymphocytes from guinea pigs not presensitized to SPE responded nonspecifically to SPE types B and C. Guinea pig lymphocytes from SPE A-presensitized animals showed enhanced proliferation over controls when treated with SPE B, suggesting that a degree of cross-reactivity between SPE types may exist, though they are serologically distinct. Mouse splenic lymphocytes exhibited low-level responsiveness to all SPE types, as would be expected for an antigen-specific proliferative response. Unlike mouse splenic lymphocytes, rabbit spleen cells and human cord blood, lymphocytes responded nonspecifically to all SPE types. Although rabbit spleen cells and human cord blood lymphocytes responded nonspecifically, the maximum response occurred at day 4 or 5, comparable to an antigen-specific system rather than a day 2 or 3 such as that with the nonspecific thymus-derived cell mitogen, concanavalin A.

MeSH Terms
Animals Antigens, Bacterial/immunology Exotoxins/immunology Guinea Pigs Humans Lymphocyte Activation Lymphocytes/immunology Mitogens/immunology Rabbits Streptococcus pyogenes/immunology
Chemicals
Antigens, Bacterial Exotoxins Mitogens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Barsumian E L
Schlievert P M
Watson D W
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39 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.22.3.681-688.1978
Published
1978-12-00
Pages
681-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422214
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.22.3.681-688.1978 PMC Full Text View journal details
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