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PMID: 3670305 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mouse nerve growth factor gene: structure and expression.

Molecular and cellular biology ·Vol. 7 ·No. 9 ·1987-09-00 ·Pages 3057-64

Selby MJ, Edwards R, Sharp F, Rutter WJ

Abstract

The organization and biologically significant sequences of the entire mouse nerve growth factor (NGF) gene have been determined. The gene spans 45 kilobases and contains several small 5' exons. Transcription of the gene results in four different mRNA species, which can be accounted for by alternative splicing and independent initiation from two promoters. These transcripts encode proteins which have divergent N termini and the NGF moiety at their C termini. The levels of the various NGF transcripts have been determined in different tissues and throughout postnatal development. We have also examined the expression of these transcripts in the brain in response to specific early sensory deprivation. The results suggest that the expression of NGF mRNA during postnatal development is regulated independently of the formation of complex neural networks.

MeSH Terms
Age Factors Animals Base Sequence DNA/genetics Gene Expression Regulation Genes Mice Molecular Sequence Data Nerve Growth Factors/genetics Nervous System Physiological Phenomena Promoter Regions, Genetic RNA Splicing RNA, Messenger/genetics Tissue Distribution Transcription, Genetic Vibrissae/innervation
Chemicals
Nerve Growth Factors RNA, Messenger DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Selby M J
Hormone Research Institute, University of California, San Francisco 94143.
Edwards R
Sharp F
Rutter W J
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.9.3057-3064.1987
Published
1987-09-00
Pages
3057-64
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC367937
Subset
IM
Grants
NIADDK NIH HHS · AM 21344 · United States
NINDS NIH HHS · NS07529 · United States
Databases
GENBANK
M17295, M17296, M17297, M17298, M17337
External Links
PubMed source DOI: 10.1128/mcb.7.9.3057-3064.1987 PMC Full Text View journal details
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