Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin.

Acta neurologica Scandinavica ·Vol. 76 ·No. 2 ·1987-08-00 ·Pages 86-93

Daugaard GK, Petrera J, Trojaborg W

Abstract

We describe clinical and electrophysiological findings in 8 patients with tumors of germ cell origin before and after treatment with high-dose cisplatin (800-1400 mg) combined with etoposide and bleomycin. All patients developed clinical or electrophysiological signs, or both, of a peripheral sensory neuropathy. One had in addition clinical and electrophysiological signs of CNS involvement, and 2 had a central conduction defect revealed by auditory stimulation.

MeSH Terms

Adolescent Adult Brain/drug effects Cisplatin/adverse effects,therapeutic use Dose-Response Relationship, Drug Electroencephalography Evoked Potentials/drug effects Humans Male Middle Aged Neural Conduction/drug effects Peripheral Nerves/drug effects Reaction Time/drug effects Sensory Thresholds Testicular Neoplasms/drug therapy Touch/drug effects

Chemicals

Cisplatin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Daugaard G K

Department of Oncology, Finsen Institute, Copenhagen, Denmark.

Petrera J

Trojaborg W

Article Info

Journal

Acta neurologica Scandinavica

Abbr.

Acta Neurol Scand

ISSN

0001-6314

DOI

10.1111/j.1600-0404.1987.tb03551.x

Published

1987-08-00

Pages

86-93

Language

English

Region

Denmark

NLM ID

0370336

Subset

External Links

PubMed source DOI: 10.1111/j.1600-0404.1987.tb03551.x View journal details

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Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin.

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