Lactam utilisation in Aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene intA.
Mutations in the lamA gene of Aspergillus nidulans prevent the conversion of exogenous 2-pyrrolidone (gamma-butyrolactam) to gamma-amino-n-butyrate (GABA) and also prevent the (probably analogous) utilisation of 2-piperidone (sigma-valerolactam). The lamA gene, in linkage group VIII, probably specifies a lactamase but a rôle in lactam uptake cannot be ruled out. lamA is probably under the control of the positive acting regulatory gene intA, which can integrate its expression with the expression of three other genes, specifying acetamidase, GABA transaminase, and GABA permease, respectively.
20 references, click to expand
-
Gene regulation for higher cells: a theory.Science. 1969 Jul 25;165(3891):349-57 PMID: 5789433
-
UTILIZATION OF CYCLIC AMIDES AND FORMATION OF OMEGA-AMINO ACIDS BY MICROORGANISMS.J Bacteriol. 1965 Mar;89:919-20 PMID: 14273687
-
The genetics of Aspergillus nidulans.Adv Genet. 1953;5:141-238 PMID: 13040135
-
GABA transaminase provides an alternative route of beta-alanine synthesis in Aspergillus nidulans.Mol Gen Genet. 1978 Jul 6;163(1):23-7 PMID: 355840
-
Nitrogen metabolite repression in Aspergillus nidulans.Mol Gen Genet. 1973 Nov 2;126(2):111-41 PMID: 4591376
-
The genetic analysis of regulation of amidase synthesis in Aspergillus nidulans. II. Mutants resistant to fluoroacetamide.Mol Gen Genet. 1970;108(2):107-16 PMID: 4097637
-
Multiple independent control mechanisms affecting the acetamidase of Aspergillus nidulans.Mol Gen Genet. 1978 Apr 25;161(1):59-65 PMID: 353500
-
Mutants of Aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase.J Bacteriol. 1976 Jan;125(1):42-7 PMID: 173707
-
NAD and NADP l-glutamate dehydrogenase activity and ammonium regulation in Aspergillus nidulans.J Gen Microbiol. 1973 Sep;78(1):39-46 PMID: 4148302
-
Induction and repression of amidase enzymes in Aspergillus nidulans.J Bacteriol. 1970 Aug;103(2):482-7 PMID: 5432013
-
Integrator gene in Aspergillus nidulans.Nature. 1976 Jul 15;262(5565):231-4 PMID: 778641
-
Metabolism of 2-pyrrolidone and gamma-aminobutyric acid by Pseudomonas aeruginosa.J Bacteriol. 1958 Jun;75(6):674-81 PMID: 13549371
-
The induction and repression of nitrate reductase in the fungus Aspergillus nidulans.Biochim Biophys Acta. 1966 Jan 11;113(1):51-6 PMID: 5940632
-
A gene cluster in Aspergillus nidulans with an internally located cis-acting regulatory region.Nature. 1975 Mar 6;254(5495):26-31 PMID: 1089903
-
Some genetical aspects of ornithine metabolism in Aspergillus nidulans.Mol Gen Genet. 1977 Feb 28;151(1):105-10 PMID: 325361
-
Protein measurement with the Folin phenol reagent.J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
-
Amide utilization in Aspergillus nidulans: evidence for a third amidase enzyme.J Gen Microbiol. 1975 Nov;91(1):99-109 PMID: 1104771
-
The use of p-fluorophenylalanine with 'master strains' of Aspergillus nidulans for assigning genes to linkage groups.Genet Res. 1965 Nov;6(3):352-9 PMID: 5848714
-
A mutant of Asperigillus nidulans lacking NADP-linked glutamate dehydrogenase.Mol Gen Genet. 1973 May 9;122(3):261-5 PMID: 4146234
-
A mutant of Aspergillus nidulans defective in NAD-linked glutamate dehydrogenase.Mol Gen Genet. 1975;138(2):164-71 PMID: 172777
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
