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PMID: 3688585 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Design of a multi-point laser scanned optical monitor of cardiac action potential propagation: application to microreentry in guinea pig atrium.

Annals of biomedical engineering ·Vol. 15 ·No. 6 ·1987-00-00 ·Pages 567-77

Hill BC, Courtney KR

Abstract

A system is described that uses a scanned laser beam to excite voltage-dependent fluorescence in cardiac muscle and thereby monitors propagation of the action potential. Details of the optical and electronic design are presented along with descriptions of the system performance. The scanner can monitor membrane voltage activity from 64 points simultaneously at a sample rate of 1000 samples/sec. Results are presented from a laser scan of arrhythmic guinea pig left atrium showing the complete evolution, from initiation to termination, of a functional microreentry induced by a premature stimulus.

MeSH Terms
Action Potentials Animals Atrial Function Electrophysiology/instrumentation,methods Guinea Pigs Heart/physiology In Vitro Techniques Lasers
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hill B C
Research Institute of the Palo Alto Medical Foundation, California 94301.
Courtney K R
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20 references, click to expand
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Article Info
Journal
Annals of biomedical engineering
Abbr.
Ann Biomed Eng
ISSN
0090-6964
DOI
10.1007/BF02364249
Published
1987-00-00
Pages
567-77
Language
English
Region
United States
NLM ID
0361512
Subset
IM
Grants
NHLBI NIH HHS · HL-24156 · United States
NHLBI NIH HHS · HL-25489 · United States
NCRR NIH HHS · RR 05513 · United States
External Links
PubMed source DOI: 10.1007/BF02364249 View journal details
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