According to the World Health Organization (https://covid19.who.int/), more than 651 million people have been infected by COVID-19, and more than 6.6 million of them have died. COVID-19 has spread to almost every country in the world because of air travel. Cases of COVID-19 transmission from an index patient to fellow passengers in commercial airplanes have been widely reported. This investigation used computational fluid dynamics (CFD) to simulate airflow and COVID-19 virus (SARS-CoV-2) transport in a variety of airliner cabins. The cabins studied were economy-class with 2-2, 3-3, 2-3-2, and 3-3-3 seat configurations, respectively. The CFD results were validated by using experimental data from a seven-row cabin mockup with a 3-3 seat configuration. This study used the Wells-Riley model to estimate the probability of infection with SARS-CoV-2. The results show that CFD can predict airflow and virus transmission with acceptable accuracy. With an assumed flight time of 4 h, the infection probability was almost the same among the different cabins, except that the 3-3-3 configuration had a lower risk because of its airflow pattern. Flying time was the most important parameter for causing the infection, while cabin type also played a role. Without mask wearing by the passengers and the index patient, the infection probability could be 8% for a 10-h, long-haul flight, such as a twin-aisle air cabin with 3-3-3 seat configuration.
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