Mitochondrial pyruvate carrier--a possible link between gluconeogenesis and ketogenesis in the liver.

Bioscience reports ·Vol. 7 ·No. 7 ·1987-07-00 ·Pages 593-7

Kümmel L

Abstract

Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship between gluconeogenesis and ketogenesis may thus exist in the liver at the level of mitochondrial pyruvate carrier.

MeSH Terms

Acetoacetates/pharmacology Alanine/metabolism Animals Carrier Proteins/metabolism Cells, Cultured Gluconeogenesis/drug effects Lactates/metabolism Liver/metabolism Male Membrane Transport Proteins Mitochondria, Liver/metabolism Mitochondrial Proteins Monocarboxylic Acid Transporters Pyruvates/metabolism Rats Rats, Inbred Strains Solute Carrier Proteins

Chemicals

Acetoacetates Carrier Proteins Lactates Membrane Transport Proteins Mitochondrial Proteins Monocarboxylic Acid Transporters Mpc1 protein, rat Pyruvates Solute Carrier Proteins Alanine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kümmel L

Laboratory for Endocrinology & Metabolism, Charles University, Faculty of Medicine, Prague, Czechoslovakia.

Article Info

Journal

Bioscience reports

Abbr.

Biosci Rep

ISSN

0144-8463

DOI

10.1007/BF01119777

Published

1987-07-00

Pages

593-7

Language

English

Region

England

NLM ID

8102797

Subset

External Links

PubMed source DOI: 10.1007/BF01119777 View journal details

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Mitochondrial pyruvate carrier--a possible link between gluconeogenesis and ketogenesis in the liver.

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