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PMID: 3697082 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Duchenne and Becker muscular dystrophy mutations: analysis using 2.6 kb of muscle cDNA from the 5' end of the gene.

Nucleic acids research ·Vol. 15 ·No. 23 ·1987-12-10 ·Pages 9761-9

Smith TJ, Forrest SM, Cross GS, Davies KE

Abstract

We have isolated overlapping human fetal muscle cDNAs encompassing 2.6kb which are localised very close to the 5' end of the Duchenne muscular dystrophy (DMD) gene. Using DNA from patients with deletions of previously reported genomic probes, we have mapped the exons across the region. Investigation of deletions in both DMD and Becker muscular dystrophy (BMD) patients shows the deletions to be present in 10% of cases and heterogeneous.

MeSH Terms
Adult Chromosome Deletion Cloning, Molecular/methods Exons Female Genes Humans Male Muscles/analysis Muscular Dystrophies/genetics Mutation Nucleic Acid Hybridization RNA, Messenger/analysis Translocation, Genetic
Chemicals
RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Smith T J
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK.
Forrest S M
Cross G S
Davies K E
References (12)
12 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/15.23.9761
Published
1987-12-10
Pages
9761-9
Language
English
Region
England
NLM ID
0411011
PMCID
PMC306529
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/15.23.9761 PMC Full Text View journal details
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