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PMID: 3707714 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Occurrence of lysoganglioside lyso-GM2 (II3-Neu5Ac-gangliotriaosylsphingosine) in GM2 gangliosidosis brain.

Biological chemistry Hoppe-Seyler ·Vol. 367 ·No. 3 ·1986-03-00 ·Pages 241-4

Neuenhofer S, Conzelmann E, Schwarzmann G, Egge H, Sandhoff K

Abstract

Lysoganglioside lyso-GM2 (sialylgangliotriaosylsphingosine) was detected in a brain sample of a patient with variant B of infantile GM2 gangliosidosis (Tay-Sachs disease) at a concentration of approx. 15 nmol/g wet tissue. Neither lysoganglioside lyso-GM2 nor the corresponding GM1 derivative could be detected in normal brain.

MeSH Terms
Brain Chemistry G(M2) Ganglioside/analogs & derivatives,analysis Gangliosides/analysis Humans Mass Spectrometry Reference Values Tay-Sachs Disease/metabolism
Chemicals
Gangliosides lysoganglioside G(M2) G(M2) Ganglioside
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Neuenhofer S
Conzelmann E
Schwarzmann G
Egge H
Sandhoff K
Article Info
Journal
Biological chemistry Hoppe-Seyler
Abbr.
Biol Chem Hoppe Seyler
ISSN
0177-3593
DOI
10.1515/bchm3.1986.367.1.241
Published
1986-03-00
Pages
241-4
Language
English
Region
Germany
NLM ID
8503054
Subset
IM
External Links
PubMed source DOI: 10.1515/bchm3.1986.367.1.241
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