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PMID: 372825 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transmission of allosteric effects in DNA.

Nature ·Vol. 278 ·No. 5704 ·1979-04-05 ·Pages 521-4

Hogan M, Dattagupta N, Crothers DM

Abstract

Binding of distamycin induces a cooperative transition of calf thymus DNA to a new form with higher affinity for the drug and altered structural properties.

MeSH Terms
Allosteric Regulation Animals Binding Sites Cattle Circular Dichroism DNA DNA, Bacterial Distamycins/pharmacology Escherichia coli Ethidium/metabolism Kinetics Molecular Weight Nucleic Acid Conformation/drug effects Pyrroles/pharmacology Thymus Gland
Chemicals
DNA, Bacterial Distamycins Pyrroles DNA Ethidium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hogan M
Dattagupta N
Crothers D M
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/278521a0
Published
1979-04-05
Pages
521-4
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/278521a0 View journal details
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