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PMID: 3737376 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

An ultrasensitive transducer for measurement of isometric contractile force from single heart cells.

Pflugers Archiv : European journal of physiology ·Vol. 407 ·No. 1 ·1986-07-00 ·Pages 109-15

Tung L

Abstract

A novel ultrasensitive force transducer suitable for measuring isometric forces generated by single spindle-shaped muscle cells is described. The transducer components are mechanically and electrically simple, consisting of a low power He-Ne laser, a pair of step index, glass optic fibers, and a photodiode detector circuit. To test the operation of the transducer, enzymatically isolated frog ventricular heart cells were used, having peak contractile forces on the order of 100 nN. The transducer presents a number of advantages over existing designs and has a resolution better than 2 nN. As such, it is suitable for excitation-contraction studies in single muscle cells.

MeSH Terms
Animals Biomedical Engineering In Vitro Techniques Mammals Myocardial Contraction Myocardium/cytology Ranidae Transducers
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tung L
References (22)
22 references, click to expand
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00580730
Published
1986-07-00
Pages
109-15
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
Grants
NHLBI NIH HHS · HL16152 · United States
External Links
PubMed source DOI: 10.1007/BF00580730 View journal details
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