Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620.

Antimicrobial agents and chemotherapy ·Vol. 30 ·No. 1 ·1986-07-00 ·Pages 143-6

Hirschhorn L, Neu HC

Abstract

The in vitro activity of difloxacin (A-56619) and A-56620, two new aryl-difluoroquinolones, was decreased by magnesium at 9 mM and in assay at pH 5.5 or in urine. Resistance was seen with members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus repeatedly exposed to subinhibitory concentrations of the compounds. The frequency of resistance was similar to that found for other new quinolones.

MeSH Terms

Anti-Bacterial Agents/pharmacology Bacteria/drug effects Ciprofloxacin/analogs & derivatives Drug Resistance, Microbial Fluoroquinolones Magnesium/pharmacology Piperazines/pharmacology Quinolines/pharmacology

Chemicals

Anti-Bacterial Agents Fluoroquinolones Piperazines Quinolines Ciprofloxacin difloxacin Magnesium sarafloxacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hirschhorn L

Neu H C

References (10)

10 references, click to expand

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In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620.
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.30.1.143

Published

1986-07-00

Pages

143-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC176452

Subset

External Links

PubMed source DOI: 10.1128/AAC.30.1.143 PMC Full Text View journal details

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Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620.

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