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PMID: 3754034 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.

Nature ·Vol. 320 ·No. 6058 ·1986-00-00 ·Pages 134-9

Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P

Abstract

We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.

MeSH Terms

Amino Acid Sequence Base Sequence Cloning, Molecular DNA/genetics Female Gene Expression Regulation HeLa Cells Humans Oncogenes Protein Conformation RNA Caps Receptors, Estrogen/genetics Sequence Homology, Nucleic Acid Solubility

Chemicals

RNA Caps Receptors, Estrogen DNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Green S

Walter P

Kumar V

Krust A

Bornert J M

Argos P

Chambon P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/320134a0

Published

1986-00-00

Pages

134-9

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

M11457

External Links

PubMed source DOI: 10.1038/320134a0 View journal details

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Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.

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