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PMID: 3755052 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Cimetidine absorption in humans during sucralfate coadministration.

British journal of clinical pharmacology ·Vol. 21 ·No. 5 ·1986-05-00 ·Pages 515-20

D'Angio R, Mayersohn M, Conrad KA, Bliss M

Abstract

Cimetidine absorption after a single 300 mg oral dose was evaluated in six normal subjects in the absence or presence of sucralfate. Sucralfate was ingested four times a day for 2 days prior to and for two additional doses on the day of cimetidine ingestion. Sucralfate coadministration had no statistically significant influence on the rate or extent of cimetidine absorption.

MeSH Terms
Administration, Oral Adult Aluminum/administration & dosage,pharmacology Biological Availability/drug effects Cimetidine/administration & dosage,metabolism Drug Evaluation Drug Interactions Humans Intestinal Absorption/drug effects Male Random Allocation Sucralfate
Chemicals
Sucralfate Cimetidine Aluminum
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
D'Angio R
Mayersohn M
Conrad K A
Bliss M
References (21)
21 references, click to expand
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Article Info
Journal
British journal of clinical pharmacology
Abbr.
Br J Clin Pharmacol
ISSN
0306-5251
DOI
10.1111/j.1365-2125.1986.tb02834.x
Published
1986-05-00
Pages
515-20
Language
English
Region
England
NLM ID
7503323
PMCID
PMC1401033
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2125.1986.tb02834.x PMC Full Text View journal details
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