Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.

Blood ·Vol. 142 ·No. 17 ·2023-00-26

Zhang Q, Li H, Chen X, Gu F, Zhang L, Zhang L, Chen T, Chen Q, Meng W, Wu Y, Chang H, Liu T, Chen C, Ma H, Liu Y

Abstract

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

MeSH 主题词

Animals Mice Leukemia, Promyelocytic, Acute/drug therapy,genetics Oncogene Proteins, Fusion/genetics Tretinoin/therapeutic use Retinoic Acid Receptor alpha Autoantigens Calmodulin-Binding Proteins

Article Info

Journal

Blood

Abbr.

Blood

ISSN

1528-0020

DOI

10.1182/blood.2023020619

Published

2023-00-26

Language

English

Country/Region

United States

NLM ID

7603509

External Links

PubMed source DOI: 10.1182/blood.2023020619 View journal details

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Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.

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