Home LiteratureArticle Details

PMID: 3783616 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Twelve families with fragile X(q27).

Journal of medical genetics ·Vol. 23 ·No. 5 ·1986-10-00 ·Pages 400-6

Webb T, Thake A, Todd J

Abstract

Through a community study of boys requiring special education for the severely mentally retarded, 12 families were ascertained in which the fragile X was found to be segregating. By assiduous follow up of these families, it was found that in only four of them could male transmission be ruled out from the grandparents' or great grandparents' generation and that the segregation ratios are disturbed.

MeSH Terms

Cells, Cultured Cytogenetics Female Fragile X Syndrome/genetics Genetic Carrier Screening Humans Lymphocytes/cytology Male Pedigree Sex Chromosome Aberrations/genetics

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Webb T

Thake A

Todd J

References (16)

16 references, click to expand

Expression in lymphocyte and fibroblast culture of the fragile X chromosome: a new technical approach.
Hum Genet. 1981;59(2):166-9 PMID: 7327576
Transmission of fragile (X) (q27) site from a male.
Lancet. 1981 Nov 28;2(8257):1231-2 PMID: 6118659
Fragile (X)(q27) sites in a pedigree with female carriers showing mild to severe mental retardation.
J Med Genet. 1982 Feb;19(1):44-8 PMID: 7069746
Marker X syndrome in an oriental family with probable transmission by a normal male.
Am J Med Genet. 1982 Jun;12(2):205-17 PMID: 7102725
Transmission of fragile (X)(q27) from normal male(s).
Hum Genet. 1982;61(3):262-3 PMID: 7173872
Randomized study for the treatment of adult advanced Hodgkin's disease: mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) versus lomustine, vinblastine, and prednisone.
Cancer Treat Rep. 1983 May;67(5):413-9 PMID: 6342771
The fragile X chromosome in a large Indian kindred.
Clin Genet. 1983 Apr;23(4):311-7 PMID: 6851223
Fragile X trait in a large kindred: transmission also through normal males.
J Med Genet. 1983 Aug;20(4):286-9 PMID: 6620329
The marker (X) syndrome: a cytogenetic and genetic analysis.
Ann Hum Genet. 1984 Jan;48(Pt 1):21-37 PMID: 6712153
Transmission of the marker X syndrome trait by unaffected males: conclusions from studies of large families.
Hum Genet. 1984;67(4):419-27 PMID: 6593289
Further segregation analysis of the fragile X syndrome with special reference to transmitting males.
Hum Genet. 1985;69(4):289-99 PMID: 3838733
A community study of severe mental retardation in the West Midlands and the importance of the fragile X chromosome in its aetiology.
J Med Genet. 1985 Aug;22(4):258-66 PMID: 4045951
Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27).
N Engl J Med. 1980 Sep 18;303(12):662-4 PMID: 6931286
Familial X-linked mental retardation and fragile X chromosomes in two Swedish families.
Clin Genet. 1981 Feb;19(2):101-10 PMID: 7193540
FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.
Am J Hum Genet. 1981 Mar;33(2):234-42 PMID: 6452060
5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.
J Med Genet. 1981 Oct;18(5):374-6 PMID: 6460104

Article Info

Journal

Journal of medical genetics

Abbr.

J Med Genet

ISSN

0022-2593

DOI

10.1136/jmg.23.5.400

Published

1986-10-00

Pages

400-6

Language

English

Region

England

NLM ID

2985087R

PMCID

PMC1049775

Subset

External Links

PubMed source DOI: 10.1136/jmg.23.5.400 PMC Full Text View journal details

Analysis Services

Twelve families with fragile X(q27).

Contact

WeChat Official Account