Inhibition in vivo of both infective Leishmania major and L. mexicana amazonensis mediated by a single monoclonal antibody.

Transactions of the Royal Society of Tropical Medicine and Hygiene ·Vol. 80 ·No. 2 ·1986-00-00 ·Pages 258-60

Debons-Guillemin MC, Vouldoukis I, Roseto A, Alfred C, Chopin C, Ploton I, Monjour L

Abstract

Monoclonal antibodies raised against a strain of Leishmania infantum isolated in Greece were produced and tested for their protective effect in an in vivo system (in BALB/C mice). A single monoclonal antibody, IgG2b isotype, can prevent the development of two Leishmania strains in vivo: one of L. major and one of L. mexicana amazonensis. This antibody-mediated protection may be dependent on complement.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Female Immunization Immunoglobulin G/immunology Leishmania mexicana Leishmania tropica Leishmaniasis/prevention & control Mice Mice, Inbred BALB C

Chemicals

Antibodies, Monoclonal Immunoglobulin G

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Debons-Guillemin M C

Vouldoukis I

Roseto A

Alfred C

Chopin C

Ploton I

Monjour L

References (13)

13 references, click to expand

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Article Info

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Abbr.

Trans R Soc Trop Med Hyg

ISSN

0035-9203

DOI

10.1016/0035-9203(86)90030-1

Published

1986-00-00

Pages

258-60

Language

English

Region

England

NLM ID

7506129

PMCID

PMC7107255

Subset

External Links

PubMed source DOI: 10.1016/0035-9203(86)90030-1 PMC Full Text View journal details

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Inhibition in vivo of both infective Leishmania major and L. mexicana amazonensis mediated by a single monoclonal antibody.

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