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PMID: 3796601 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Dissociated expression of c-myc and a fos-related competence gene during cardiac myogenesis.

Molecular and cellular biology ·Vol. 6 ·No. 11 ·1986-11-00 ·Pages 4140-3

Schneider MD, Payne PA, Ueno H, Perryman MB, Roberts R

Abstract

Cardiac myocytes irreversibly lose their proliferative capacity soon after birth, and cardiac DNA synthesis becomes uncoupled from mitotic division. Therefore, we examined cardiac muscle for developmental down regulation of inducible proto-oncogenes associated with cell proliferation. c-myc mRNA decreased continuously from day 13 of embryonic development and was dissociated from expression of the fos-related gene r-fos, which decreased precipitously between days 3 and 7 after birth.

MeSH Terms
Animals Cell Differentiation Cells, Cultured Embryo, Mammalian Heart/embryology Myocardium/cytology Nucleic Acid Hybridization Oncogenes RNA, Messenger/genetics,isolation & purification Rats Transcription, Genetic
Chemicals
RNA, Messenger
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schneider M D
Payne P A
Ueno H
Perryman M B
Roberts R
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37 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.6.11.4140-4143.1986
Published
1986-11-00
Pages
4140-3
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC367187
Subset
IM
Grants
NCRR NIH HHS · RR-05425 · United States
External Links
PubMed source DOI: 10.1128/mcb.6.11.4140-4143.1986 PMC Full Text View journal details
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