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PMID: 3800879 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sickle cell membranes and oxidative damage.

The Biochemical journal ·Vol. 237 ·No. 1 ·1986-07-01 ·Pages 265-9

Rice-Evans C, Omorphos SC, Baysal E

Abstract

Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease.

MeSH Terms
Anemia, Sickle Cell/blood Antioxidants/pharmacology Ascorbic Acid/pharmacology Deferoxamine/pharmacology Erythrocyte Membrane/drug effects,metabolism Erythrocytes, Abnormal/drug effects,metabolism Free Radicals Humans In Vitro Techniques Iron/pharmacology Oxidation-Reduction
Chemicals
Antioxidants Free Radicals Iron Deferoxamine Ascorbic Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rice-Evans C
Omorphos S C
Baysal E
References (35)
35 references, click to expand
  1. Studies on the formation of Heinz bodies. I. Methemoglobin production and oxyhemoglobin destruction.
    Blood. 1960 Dec;16:1722-35 PMID: 13711606
  2. Improved method for the determination of blood glutathione.
    J Lab Clin Med. 1963 May;61:882-8 PMID: 13967893
  3. Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles.
    Can J Biochem. 1969 May;47(5):485-92 PMID: 5787688
  4. A novel phospholipid in irreversibly sickled cells: evidence for in vivo peroxidative membrane damage in sickle cell disease.
    Blood. 1984 Feb;63(2):362-7 PMID: 6692040
  5. The interaction of 1-anilino-8-naphthalene sulphonate with erythrocyte membranes.
    FEBS Lett. 1969 Apr;3(2):150-152 PMID: 11946993
  6. Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine.
    Biochem J. 1979 Nov 15;184(2):469-72 PMID: 230833
  7. Denatured hemoglobin in sickle erythrocytes.
    J Clin Invest. 1977 Apr;59(4):633-40 PMID: 845254
  8. Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation of normal and sickled erythrocytes.
    Br J Haematol. 1980 Jan;44(1):87-92 PMID: 7378296
  9. Energy reserve and cation composition of irreversibly sickled cells in vivo.
    Br J Haematol. 1978 Dec;40(4):527-32 PMID: 728369
  10. Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems?
    FEBS Lett. 1978 Aug 15;92(2):321-6 PMID: 212302
  11. Phosphorus assay in column chromatography.
    J Biol Chem. 1959 Mar;234(3):466-8 PMID: 13641241
  12. Oxidative effects of iron on erythrocytes.
    Free Radic Res Commun. 1985;1(1):55-62 PMID: 3880015
  13. t-butyl hydroperoxide-induced perturbations of human erythrocytes as a model for oxidant stress.
    Biochim Biophys Acta. 1985 May 28;815(3):426-32 PMID: 3995035
  14. The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.
    Arch Biochem Biophys. 1963 Jan;100:119-30 PMID: 14028302
  15. Decreased [3H]serotonin and [3H]spiperone binding consequent to lipid peroxidation in rat cortical membranes.
    Biochem Biophys Res Commun. 1982 Feb 11;104(3):1003-10 PMID: 7073721
  16. Abnormal redox status of membrane-protein thiols in sickle erythrocytes.
    J Clin Invest. 1985 May;75(5):1531-7 PMID: 3998148
  17. Erythrocyte membrane lipid reorganization during the sickling process.
    Br J Haematol. 1979 Feb;41(2):223-34 PMID: 427032
  18. A spectrofluorimetric study of the interaction of glycerol mono-oleate with human erythrocyte ghosts.
    FEBS Lett. 1976 Oct 15;69(1):45-50 PMID: 992044
  19. Failure to demonstrate red cell membrane protein abnormalities in sickle cell anaemia.
    Br J Haematol. 1980 Dec;46(4):627-9 PMID: 7437340
  20. Spontaneous oxygen radical generation by sickle erythrocytes.
    J Clin Invest. 1982 Dec;70(6):1253-9 PMID: 6294138
  21. Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles.
    J Clin Invest. 1985 Jan;75(1):266-71 PMID: 2578138
  22. Tissue sulfhydryl groups.
    Arch Biochem Biophys. 1959 May;82(1):70-7 PMID: 13650640
  23. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.
    J Biol Chem. 1984 Mar 25;259(6):3620-4 PMID: 6323433
  24. Red cell membrane injury in sickle cell anaemia.
    Br J Haematol. 1977 Jan;35(1):1-9 PMID: 322695
  25. The role of vitamin E in biological membranes.
    Ciba Found Symp. 1983;101:45-55 PMID: 6557907
  26. A rapid method of total lipid extraction and purification.
    Can J Biochem Physiol. 1959 Aug;37(8):911-7 PMID: 13671378
  27. Elevated erythrocyte calcium in sickle cell disease.
    Nature. 1973 Nov 9;246(5428):105-6 PMID: 4585849
  28. Oxygen toxicity, oxygen radicals, transition metals and disease.
    Biochem J. 1984 Apr 1;219(1):1-14 PMID: 6326753
  29. Fluorescent products of phospholipids during lipid peroxidation.
    Lipids. 1973 Apr;8(4):203-7 PMID: 4695132
  30. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  31. Interaction of sickle cell hemoglobin with erythrocyte membranes.
    Proc Natl Acad Sci U S A. 1981 Jan;78(1):65-8 PMID: 6941263
  32. Abnormal vitamin E and glutathione peroxidase levels in sickle cell anemia: evidence for increased susceptibility to lipid peroxidation in vivo.
    J Lab Clin Med. 1979 Oct;94(4):542-8 PMID: 479666
  33. Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells.
    J Clin Invest. 1976 Oct;58(4):955-63 PMID: 965498
  34. Aging human erythrocytes. Differential sensitivity of young and old erythrocytes to hemolysis induced by peroxide in the presence of thyroxine.
    Arch Biochem Biophys. 1976 Jun;174(2):463-8 PMID: 1230004
  35. Studies on the altered membrane characteristics of sickle cells.
    FEBS Lett. 1978 Oct 1;94(1):81-6 PMID: 700141
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2370265
Published
1986-07-01
Pages
265-9
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1146974
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2370265 PMC Full Text View journal details
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