Fat synthesis in adipose tissue. An examination of stoichiometric constraints.

The Biochemical journal ·Vol. 238 ·No. 3 ·1986-09-15 ·Pages 781-6

Fell DA, Small JR

Abstract

The requirement for net balance of synthesis, degradation and transport for all intermediates in the pathways from glucose to fat imposes constraints on the balance of fluxes between different pathways. Linear programming has been used to examine the interactions between these constraints on metabolism in adipocytes and the requirement for efficiency in the conversion of glucose into fat. The circumstances under which excessive ATP synthesis would accompany this conversion have been investigated.

MeSH Terms

Adipose Tissue/metabolism Animals Biological Transport Glucose/metabolism Lipids/biosynthesis Models, Biological NADP/metabolism Pentose Phosphate Pathway Rats Triglycerides/biosynthesis

Chemicals

Lipids Triglycerides NADP Glucose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fell D A

Small J R

References (11)

11 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2380781

Published

1986-09-15

Pages

781-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1147204

Subset

External Links

PubMed source DOI: 10.1042/bj2380781 PMC Full Text View journal details

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Fat synthesis in adipose tissue. An examination of stoichiometric constraints.

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