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PMID: 3834837 Published · ppublish English Journal Article

Norfloxacin penetration into human renal and prostatic tissues.

Antimicrobial agents and chemotherapy ·Vol. 28 ·No. 2 ·1985-08-00 ·Pages 349-50

Bergeron MG, Thabet M, Roy R, Lessard C, Foucault P

Abstract

Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined in 14 patients. Mean ratios of norfloxacin concentration in tissue over concentration in serum were 6.6 +/- 2.8 for the kidney and 1.7 +/- 0.2 for the prostate samples. The levels were above the MICs of most urinary pathogens.

MeSH Terms
Aged Humans Kidney/metabolism Kidney Cortex/metabolism Kidney Medulla/metabolism Male Middle Aged Norfloxacin/metabolism Prostate/metabolism Urinary Tract Infections/drug therapy
Chemicals
Norfloxacin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bergeron M G
Thabet M
Roy R
Lessard C
Foucault P
References (11)
11 references, click to expand
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  9. Norfloxacin: activity against urinary tract pathogens and factors influencing the emergence of resistance.
    J Antimicrob Chemother. 1984 Apr;13(4):315-23 PMID: 6233248
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    Antimicrob Agents Chemother. 1985 Mar;27(3):297-301 PMID: 3158272
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.28.2.349
Published
1985-08-00
Pages
349-50
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180245
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.28.2.349 PMC Full Text View journal details
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