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PMID: 3838965 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Chromosomes of human sperm: variability among normal individuals.

Human genetics ·Vol. 70 ·No. 1 ·1985-00-00 ·Pages 18-24

Brandriff B, Gordon L, Ashworth L, Watchmaker G, Moore D, Wyrobek AJ, Carrano AV

Abstract

The chromosomal constitution of 2468 human sperm cells has been investigated by fusion of human sperm with hamster eggs. The overall frequency of cells with structural aberrations was 7.7%, ranging from 1.9% to 15.8%, and varying significantly among individuals. The highest frequency occurred in sperm from the oldest donor (49 years), who also had had a vasectomy reversal three years prior to sampling. The overall aneuploidy frequency was 1.7%, ranging from 0.6% to 3.1%. In nine out of ten donors from whom blood samples were available the frequency of sperm cells with structural aberrations was higher than that for lymphocytes. Two previously reported donors (Brandriff et al. 1984) were resampled after an interval of 14 and 16 months respectively, and were each found to have similar frequencies of sperm chromosome abnormalities at both sampling times. A father-son pair included in the study had several chromosome breakpoints in common, although no more frequently than unrelated individuals.

MeSH Terms
Adult Age Factors Aneuploidy Animals Chromosome Aberrations Cricetinae Female Genetic Variation Humans Karyotyping Lymphocytes/ultrastructure Male Middle Aged Sperm-Ovum Interactions Spermatozoa/ultrastructure Time Factors
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Brandriff B
Gordon L
Ashworth L
Watchmaker G
Moore D
Wyrobek A J
Carrano A V
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00389451
Published
1985-00-00
Pages
18-24
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00389451 View journal details
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