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PMID: 3857597 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Capillary number and percentage closed in human diabetic sural nerve.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 8 ·1985-04-00 ·Pages 2513-7

Dyck PJ, Hansen S, Karnes J, O'Brien P, Yasuda H, Windebank A, Zimmerman B

Abstract

The number of capillaries per mm2, minimum intercapillary distance, number of endothelial nuclei per capillary section, and percentage of capillaries closed were evaluated in transverse sections of fascicles of 45 control and 36 diabetic sural nerves. All controls and patients were prospectively studied to ascertain their diabetic and neuropathic status. An index of pathology was introduced and it was found to provide a sensitive and reliable measurement of the presence and severity of neuropathy. The number of capillaries and minimum intercapillary distance of diabetic nerves were not significantly different from those of controls (P greater than 0.05). Diabetic nerves exhibited a small but statistically significant increase in the number of endothelial nuclei per capillary that was positively correlated with the severity of neuropathy. The most striking abnormality was the statistically significant increase in the percentage of capillaries closed in patients with neuropathy as compared to those without neuropathy and controls. Among diabetics, this percentage increased with the severity of neuropathy (P = 0.008). The two capillary abnormalities that have been demonstrated may play a role in the development of diabetic polyneuropathy.

MeSH Terms
Adult Age Factors Capillaries/pathology Cell Nucleus/pathology Diabetes Mellitus/pathology Diabetic Neuropathies/pathology Endothelium/pathology Female Humans Male Middle Aged Spinal Nerves/blood supply Sural Nerve/blood supply,pathology
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Dyck P J
Hansen S
Karnes J
O'Brien P
Yasuda H
Windebank A
Zimmerman B
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.8.2513
Published
1985-04-00
Pages
2513-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397589
Subset
IM
Grants
NINDS NIH HHS · NS14304 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.8.2513 PMC Full Text View journal details
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