Dominant lethal study in male mice treated with ofloxacin, a new antimicrobial drug.

Mutation research ·Vol. 144 ·No. 1 ·1985-09-00 ·Pages 51-5

Shimada H, Ebine Y, Sato T, Kurosawa Y, Arauchi T

Abstract

Ofloxacin (OFLX) in a single dose (250 or 2500 mg/kg) or 5 consecutive daily doses (125 or 1250 mg/kg) produced no dominant lethal mutational effects in male BDF1 strain mice during an 8-week mating schedule. Methyl methanesulfonate (MMS), used as a positive control, produced dominant lethal mutations within 1-3 weeks of mating.

MeSH Terms

Animals Anti-Bacterial Agents/administration & dosage,pharmacology,toxicity Female Fetal Death/chemically induced,genetics Genes, Dominant Genes, Lethal Litter Size/drug effects Male Mice Mutation Ofloxacin Oxazines/administration & dosage,pharmacology,toxicity Pregnancy Spermatozoa/drug effects

Chemicals

Anti-Bacterial Agents Oxazines Ofloxacin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Shimada H

Ebine Y

Sato T

Kurosawa Y

Arauchi T

Article Info

Journal

Mutation research

Abbr.

Mutat Res

ISSN

0027-5107

DOI

10.1016/0165-7992(85)90123-x

Published

1985-09-00

Pages

51-5

Language

English

Region

Netherlands

NLM ID

0400763

Subset

External Links

PubMed source DOI: 10.1016/0165-7992(85)90123-x View journal details

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Dominant lethal study in male mice treated with ofloxacin, a new antimicrobial drug.

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