GTP enhances inositol trisphosphate-stimulated Ca2+ release from rat liver microsomes.

FEBS letters ·Vol. 185 ·No. 1 ·1985-06-03 ·Pages 147-50

Dawson AP

Abstract

Low concentrations of GTP (10-50 microM) greatly enhance the inositol 1,4,5-trisphosphate stimulated Ca2+ release from rat liver microsomal vesicles. The effect of GTP depends on the presence of low concentrations of polyethylene glycol in the incubation medium. Guanylyl imidodiphosphate is ineffective at mimicking the GTP effect and inhibits the action of GTP added subsequently.

MeSH Terms

Animals Calcium/metabolism Female Guanosine Triphosphate/pharmacology Guanylyl Imidodiphosphate/pharmacology Inositol 1,4,5-Trisphosphate Inositol Phosphates/pharmacology Microsomes, Liver/drug effects,metabolism Polyethylene Glycols/pharmacology Rats Sugar Phosphates/pharmacology

Chemicals

Inositol Phosphates Sugar Phosphates Guanylyl Imidodiphosphate Polyethylene Glycols Inositol 1,4,5-Trisphosphate Guanosine Triphosphate Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Dawson A P

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(85)80759-6

Published

1985-06-03

Pages

147-50

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(85)80759-6 View journal details

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GTP enhances inositol trisphosphate-stimulated Ca2+ release from rat liver microsomes.

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